Alvina Nur Laili

Biology Department, Faculty of Mathematics and Natural Sciences, Jember University, East Java, Indonesia

Adriana Iflaha

Biology Department, Faculty of Mathematics and Natural Sciences, Jember University, East Java, Indonesia

Kaysha Rahmadita Widyadana

Biology Department, Faculty of Mathematics and Natural Sciences, Jember University, East Java, Indonesia

Zahniar

Faculty of Medicine, University of Jember, Indonesia

Dyah Rahmadhani Saraswati

Faculty of Medicine, University of Jember, Indonesia

Syubbanul Wathon

Biology Department, Faculty of Mathematics and Natural Sciences, Jember University, East Java, Indonesia

Rike Oktarianti

Biology Department, Faculty of Mathematics and Natural Sciences, Jember University, East Java, Indonesia

Kartika Senjarini

Biology Department, Faculty of Mathematics and Natural Sciences, Jember University, East Java, Indonesia

DOI: https://doi.org/10.19184/lsb.v2i1.48353

ABSTRACT 

The salivary glands of mosquitoes, which act as disease vectors, contain biological components that facilitate the blood-feeding process and transmit pathogens to the human body. Apyrase, a protein from the salivary glands of Aedes aegypti, is known to be an immunogenic protein that influences the host's immunity. It can prevent platelet aggregation by hydrolyzing ATP or ADP into AMP and thus facilitate the blood-feeding process. This mechanism is also exploited by pathogens to obtain entry into the host's body. Vaccination with the apyrase protein could control dengue virus transmission by enhancing the immune response to inhibit the pathogen's entry. To examine the potential of apyrase, it is critical to explore its nature and characteristics by using bioinformatics databases. This quantitative descriptive study involved apyrase protein from the salivary glands of Ae. aegypti obtained from several bioinformatics databases, namely UniProt, SWISSMODEL, ENZYME, Rhea, CFSSP, GlyCosmos, STRING, and QuickGo. The findings contribute to a more fine-cut understanding of apyrase as a potential vaccine to inhibit dengue transmission.

Keywords: apyrase, immunogenic, pathogen, transmission, vaccine.