Fahma Wardah Sururin

Biology Department, Faculty of Mathematics and Natural Sciences, University of Jember, Indonesia

Nida An Khafiyya

Faculty of Medicine, University of Jember, Indonesia

DOI: https://doi.org/10.19184/lsb.v2i1.47444

ABSTRACT 

Calotropis gigantea (L.) W.T.Aiton, a wild plant thriving in arid environments, has been traditionally used for medicinal purposes by communities near Baluran National Park (BNP). The latex of C. gigantea is used as a crab poison due to its ability to cause fatal damage and separation of body parts, possibly related to chitin disruption in insects. This study explores the potential insecticidal properties of secondary metabolites in C. gigantea using Prediction of Activity Spectra for Substance (PASS) Online. Out of 68 identified secondary metabolites, six show significant insecticidal potential, namely Profenophos, Ethion, Alpha-Citral, 1-Phenylethyl acetate, (E)-dec-3-en-2-one, and Benzaldehyde. Notably, Profenophos, Ethion, Alpha-Citral, and Benzaldehyde exhibit toxic properties effective against insects, with enzyme inhibitory activity affecting nerve signaling and immune systems, suggesting potential for bio-insecticide development.

Keywords: Biduri, Calotropis gigantea, PASS Online, Secondary Metabolite, Insecticide Potency.